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Three in ten victims are civilians, the Syrian Observatory for Human Rights said. 15,000 children have lost their lives since 2011.
More than 86,000 civilians are among the 301,781 people killed in the Syrian war since March 2011, the Syrian Observatory for Human Rights said.
The civilian toll includes 15,099 children and 10,018 women.
Rebel fighters made up 52,359 of those killed.
A total of 59,006 Syrian soldiers have been killed, in addition to 48,048 other pro-government fighters from countries including Iraq, Iran and Lebanon as well as Syria.
Jihadists of Daesh and the onetime Al-Qaeda affiliate now renamed the Fateh al-Sham Front accounted for 52,031 of the dead.
The Observatory said another 3,645 victims could not be identified.
The figure is an increase of nearly 9,000 on the last death toll published by the Observatory in early August.
The United Nations and the major powers have made repeated efforts to end the bloodshed in Syria but all have so far failed.
A new ceasefire brokered by Russia and the USA went into effect at sundown on Monday 12th September.